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Outcomes outside of the testing hierarchy, such as occurrence of diabetes-related morbidity (e.g., individual component of MACE or expanded composite CV outcome), change in blood pressure, and HRQoL, need to be interpreted with caution due to the possible inflated type I error

Heerspink HJL, Stefnsson BV, Correa-Rotter R, Chertow GM, Greene T, Hou F-F, Mann JFE, McMurray JJV, Lindberg M, Rossing P, Sjstrm CD, Toto RD, Langkilde A-M, Wheeler DC

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Adding electrolyte beveragesespecially those containing sodium and potassiumcan help restore mineral balance more effectively than water alone

What does the clinical evidence say about TRT plus GLP-1 efficacy

provide important new information that further illuminates pathways and strategies to optimize the use of new GLP-1R agonists for the treatment of human subjects with diabetes and/or obesity