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As with other medications, prescribers may prescribe these medications for off-label purposes, provided it aligns with the accepted standard of care and falls within their scope of practice

Significant reductions in body weight and improvements in glycaemic control have been demonstrated in early-phase clinical trials, most notably the Phase 2 trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)

That is why it works as a once-weekly injection, unlike older GLP-1 agonists that required daily dosing

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