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Diabetes (Type 2) Available in NZ = Dulaglutide (Trulicity, weekly injection) or Liraglutide (Victoza, daily injection)

Indeed, it has now become apparent that rates of nausea and vomiting can be greatly reduced with much slower titration regimens, as has been the case in development of titratable GLP-1insulin combination therapies

Many peptide drugs require daily injections, which may affect their tolerance and patient compliance

Theyre typically mild and temporary, often resolving as doses are gradually increased

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However, selective knockdown of GLP-1R in the DVC only partially perturbs normal energy balance, whereas GLP-1R knockdown in the hypothalamus does not result in any energy balance impairment 60