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Natural GLP-1 receptor agonist: The kingdom of plants has great promise for the development of novel medications to treat a range of conditions, including diabetes mellitus

GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, an incretin hormone released from intestinal L-cells in response to food intake

Kristina L

Semaglutide attenuates anxious and depressive-like behaviors and reverses the cognitive impairment in a type 2 diabetes mellitus mouse model via the microbiotagutbrain axis

GLP-1, GIP, and glucagon

Tirzepatide acts on two receptors (GLP-1 and GIP) and produces stronger appetite suppression and faster weight loss than semaglutide, but it also carries higher rates of early nausea and gastric upset