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Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis

An individual with IFG and/or IGT may have an HbA1c 41 mmol/L at baseline, but they should still be diagnosed and coded as pre-diabetes

Strategy 15: consider temporary dose reduction If fatigue significantly impairs your quality of life and does not respond to the strategies above, discuss a temporary dose reduction with your healthcare provider

In addition, DPP-4 inhibitors should not be initiated in a patient with a history of pancreatitis

For spinal cord staining, we used mice not injected with AAV-9

Other than a slight increase in the diabetes interpersonal distress scale among the 18 participants completing both baseline and 3-6 month DDS surveys ( p =0.03), there was no statistically significant difference in any of the survey scores obtained at baseline when compared to 10-day or at 3-6 month follow up (See Table 3 )