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Meyerhof, W., Beisiegel, U

Reduce if gastrointestinal symptoms remain severe after six or more weeks at a given dose level, if significant dehydration results from persistent vomiting or diarrhea, if heart rate increases beyond 15 beats per minute above baseline, or if the side effect burden is causing protocol abandonment

doi: 10.1080/08870446.2010.540664.938640058 [DOI] [PubMed] [Google Scholar] 48.Wing RR, Jeffery RW

So, theyll petition the FDA

Consistent with this concept, up to 30% of individuals with PsO eventually develop PsA, a chronic inflammatory arthropathy affecting peripheral joints, entheses, and the axial skeleton (10)

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