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Slowed Digestion: They delay how quickly food leaves the stomach, which supports prolonged satiety after meals

Ozempic is an FDA-approved GLP-1 (glucagon-like peptide-1) receptor agonist, which is injected subcutaneously once weekly

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Indeed, we have reported that GLP-1 receptors are expressed in NTS and AP neurons and are depolarized by administration of GLP-1 30

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Thus, for a number of them, even if they are good substrates in vitro , other clearance pathways may be more important in vivo or, if they are cleaved by DPP-4, removal of the N-terminal dipeptide may have no effect upon their biological activity