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If drugs to mitigate nausea (or other GI AEs) are needed for over a month when the maintenance GLP-1 RA dose has been reached, a dose reduction should be considered for the patient to tolerate the drug with no need for pharmacological support [35]

is a consultant to Pfizer and Novo Nordisk

Simultaneously, estrogen withdrawal directly worsens insulin sensitivity through its own mechanisms, compounding the metabolic burden that visceral fat accumulation creates

Intraperitoneal GLP-1 was shown to lower plasma glucose in GLP-1R knockdown mice without increasing insulin secretion, whereas intravenous GLP-1 did not affect glucose or insulin levels

Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis

eClinicalMedicine 58 , 101882 (2023)