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It is important to appreciate, however, that the increased risk relates to a disorder that is relatively uncommon. Given the numbers of participants who have been recruited to clinical trials and the large number of people globally who use GLP-1 RAs, we should be confident that if corroborated, the absolute risk of developing NAION in direct relation to taking semaglutide must indeed be rare, Susan Mollan, MBcHP, of University Hospitals Birmingham NHS Foundation Trust , in England, wrote in a commentary published with the study

doi: 10.1152/ajpendo.00460.2007

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For drawing your actual doses after reconstitution, use 1 mL insulin syringes with fixed 29-31 gauge needles

Treatment with semaglutide tablets 14 mg once daily for 26 weeks resulted in statistically significant reductions in HbA1c compared to placebo