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Suppresses Glucagon Secretion: It also acts on the alpha cells of the pancreas to reduce the secretion of glucagon, a hormone that tells the liver to release stored glucose

However, no statistically significant effect of metformin was observed in plasma homocysteine (metabolite that plays a critical role in DNA methylation) concentrations in PCOS patients with or without metformin treatment (117)

Patients often want to get to the effective dose quickly, but rushing can make side effects harder than they need to be
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