why does semaglutide cause muscle loss matters: the effects of medically induced weight on skeletal muscle semaglutide effect on muscle mass

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Dryden-Peterson, S., Kim, A., Kim, A

Key Points Native human GLP-1 normalizes hyperglycaemia in patients with type 2 diabetes mellitus, but the short in vivo half-life of this hormone limits its therapeutic application A number of synthetic GLP-1 receptor agonists, with half-lives between 23 h and several days, have been developed for the long-term treatment of type 2 diabetes mellitus Short-acting GLP-1 receptor agonists (such as exenatide and lixisenatide) predominantly lower postprandial glucose levels and insulin concentrations via retardation of gastric emptying Long-acting GLP-1 receptor agonists (such as albiglutide, dulaglutide, exenatide long-acting release and liraglutide) predominantly lower blood glucose levels through stimulation of insulin secretion and reduction of glucagon levels Adverse effects of GLP-1 receptor agonists include nausea, vomiting and diarrhoea, injection-site reactions, antibody formation and increased heart rate This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

Clinical trials show semaglutide causes mean increases in resting heart rate of approximately 2-4 beats per minute compared to baseline

Reasons for weight Gain: Poor Nutrition Alcohol Sleep Disturbances Hormones Thyroid Disorder Metabolic Disorders Lack of Activity / Exercise It is important to have discussions on lifestyle and what that currently looks like and what it needs to look like to obtain a weight loss goal

This is why many clinicians recommend: Gradual dose reductions Close monitoring of hunger and weight trends Adjustments based on real-world response Stopping suddenly is more likely to result in regain than a guided transition