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Many of us are seeing patients on GLP-1 medications report less interest in drinking or fewer cravings to use drugs

A degradation of extracellular ATP to adenosine diphosphate (ADP) is mediated enzymatically by ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) in type I cells, which in turn increases the response to sweet stimuli by binding of ADP to adenosine 2B (A2B) receptors in type II cells [39]

This often leads to a significant decrease in food consumption

How Amazon Combined Primary Care, Pharmacy, and Weight Loss in One Program Most GLP-1 programs on the market today operate in silos

A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation