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Future research should delve deeper into the interaction between central and peripheral energy metabolism organs, with a focus on appetite regulation as an entry point, to further explore the neural circuits in acupuncture studies

The cell bodies of vagal afferent nerves are found in the nodose ganglia

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The pathways with the strongest human-relevant evidence are the peripheral anti-inflammatory effects (reduction in systemic hs-CRP and cytokines) and the systemic metabolic improvements (glycemic control, weight reduction), both of which are well-documented in clinical data

Through such comprehensive genetic analyses, PRSs holds the potential to advance our ability to tailor preventive and therapeutic strategies based on individual genetic risk profiles, paving the way for precision medicine for IR-psychiatric multimorbidity