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In the real-world settings, however, selection of antiobesity medications is not solely based on efficacy but also depends on other factors such as previous attempts to lose weight, comorbid medical conditions, coadministration of other medications, adverse effects from medications, insurance coverage, and patient preferences

Common symptoms include: Mild redness Itching or warmth Swelling or firmness under the skin Tenderness or soreness A small raised bump Most reactions appear within hours to a few days after the injection and improve on their own

doi: 10.1016/j.bioorg.2024.107221 55

This needle-free option can be a convenient alternative for those who prefer not to use injections

The SURMOUNT-1 clinical trial tracked weight loss outcomes across all three maintenance dose tiers over 72 weeks in adults with obesity or overweight

Combining with naltrexone/bupropion, orlistat, or topiramate has not been well-studied and should be approached cautiously under medical supervision