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Weight management in type 2 diabetes For type 2 diabetes patients who are overweight or obese (which describes the majority), GLP-1 medications address both the glycemic and the weight components of their disease

(2017, April 7)

Some drugs for the treatment of T2DM may cause systemic side-effects such as hypoglycemia, and the long-term administration of insulin could promote brain insulin resistance (17)

When this happens, GLP-1 medications lose their effectiveness because there are insufficient beta cells to respond to the GLP-1 signal

Articles were reviewed for efficacy at reducing A1c (Tables 1 and 2) or for other clinical effects including effect on weight, blood pressure (BP), or other drug-related outcomes

Aside from the advantage of having higher appeal to people who are squeamish with needles, oral formulations remove the need for cold chain storage for injectable forms of GLP1R/GIPR/GR agonists , which otherwise must be stored at cold temperatures if not provided in a dry (Tablet/pill) form