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Some people do just fine and see the effects they're looking for on the introductory 0.25 mg dose or on the first main phase of 0.5 mg doses

The primary adverse reaction to EX is nausea, suggesting that nausea may be the primary mechanism of weight loss (52)
With less than one-third of statin users meeting LDL goals (per Joerg Koglin, Mercks Head of General Medicine), a once-daily oral PCSK9 inhibitor could open this market to millions of undertreated patients especially in primary care and emerging economies

Common side effects during this phase include mild nausea, particularly in the first 48 hours after injection

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