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Studies show that the synthetic versions of GLP-1 (semaglutide and tirzepatide) used in medications can reshape the gut microbiome composition

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Immunohistochemical determination of the site of hypotensive effects of glucagon-like peptide-2 in the rat brain

Levels of GIP expression (in K-cells) are greatest in the proximal gut, and circulating levels of GIP rapidly increase upon food intake [236,325,326] or when nutrients are placed directly into the duodenum [289,323,327]

These effects particularly are relevant in preventing adverse remodeling and heart failure progression [43]

Findings: In animal studies, long-acting GLP-1 analogs improved glucose tolerance and enhanced insulin response, supporting their role in metabolic regulation