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In the UK, Wegovy is recommended by NICE (TA875) for managing weight in adults with a BMI of 35 kg/m or above (or 32.5 kg/m or above for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds) with at least one weight-related comorbidity

Therefore, most of our patients experienced significant weight loss, with likely changes in food intake, which in turn alters urine chemistry

This leads to an increase in plasma GLP-1 level and improves the metabolic phenotype in HFD-fed mice [206] (Fig

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In some cases, temporary dose reduction or slower titration may allow your body to adapt while minimizing gastrointestinal side effects

& Vora, J