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Retatrutide Weight Loss: How Much At Each Dose 0:00 Welcome & todays focus: Retatrutide and chasing the biggest number 1:11 On The Pen intro, live schedule (Mon/Wed/Fri) & housekeeping 2:10 How Dave first heard about retatrutide (work trip, early phase 1 data) 3:35 Flashback clip: early excitement about retatrutide phase 3 trials 4:40 Why this new retatrutide data feels different for obesity medicine 5:32 TRIUMPH-4 trial overview: obesity + knee osteoarthritis population 7:00 Headline results: 28.7% average weight loss, surgery-level efficacy 8:47 Breaking down weight loss by dose (9 mg vs 12 mg

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In a study of transgenic mice with a Kras G12D mutation which induces PanINs and eventually pancreatic cancer, treatment with exendin-4 increased higher grade PanIN lesions (35, 38)

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Registration Open: 05/26/2025 - 04/26/2028 User Access Closed: 05/26/2028 Course Instructions Click on the Contents tab to watch the on-demand recording