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Emerging evidence suggests that MetS contributes to pain catastrophizing, with obesity acting as a key amplifier of pain perception in inflammatory diseases such as PsA (73)

Study type: animal (mechanistic) study

The study made headlines at the 2026 American Society of Clinical Oncology (ASCO) annual meeting in June

In animal studies, microneedle patches containing semaglutide or exendin-4 have lowered blood sugar and reduced body weight in mice

The receptor's large, complex binding surface, characteristic of class B GPCRs, was thought to require the extensive contact area that only a peptide could provide