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Symptoms intensify, patients avoid activity, which further promotes the onset of dyspnea and fatigue, leading to further physical inactivity and exercise intolerance

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Moreover, exendin-4 inhibits NF-B activity by hindering the breakdown of IB (NF-kappa-B inhibitor alpha) in LPS-stimulated primary microglia, which reduces the activation of microglia and the generation of pro-inflammatory cytokines [113]

31 Pharmacokinetics Exenatide concentration was evaluated by ELISA

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