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A cycle can shift because ovulation was delayed, because calorie intake dropped, because pregnancy occurred, or because another endocrine issue was already present

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The compounds affect multiple systems that require monitoring to ensure safety and optimize results

For older patients with metabolic disease, that may translate into protective effects against cognitive decline controlling insulin dynamics and reducing obesity-associated neurodegeneration could plausibly slow Alzheimer's progression, even if one major study last year did not show a clean signal
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