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Description
Genetic variants can affect the response to GLP-1 agonists for weight loss

(2) reduce clearance rate due to slowed metabolism and renal filtration (131)

Over the 20th century, additional treatments were developed and FDA approved for treatment of overweight and obesity, including phentermine, phentermine/topiramate, orlistat, and naltrexone/bupropion

The potential actions of GLP-1 medicines in modulating astrocyte-mediated neuroinflammation have not been extensively explored

Abstract Tirzepatide, a dual agonist for glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has shown robust efficacy in treating diabetes and obesity, and in obese patients with heart failure with preserved ejection fraction (HFpEF), it reduced weight, lowered blood pressure, and improved outcomes

HS: Writing original draft, Funding acquisition
