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placebo: 82) involving 189 individuals indicated no significant overall effect of fluoxetine on insulin concentrations (WMD: 15.64 pmol/L

Well monitor your progress and adjust your plan as needed.

[DOI] [PMC free article] [PubMed] [Google Scholar] 142

Depending on the trial, the target dose may be 4mg, 9mg or 12mg once weekly

While the results can be dramatic, its a major commitment

As of March 2026, two trials are actively recruiting new participants: the Maintenance trial (NCT06859268, testing dose reduction after initial weight loss) and a new enrollment trial (NCT07232719, 250 participants with obesity or overweight)
