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It was originally approved for diabetes management but became widely prescribed off-label for weight loss before Wegovy received its separate approval

Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts

The accumulated visible changes (volume loss, collagen depletion, skin laxity) do not spontaneously reverse, though some skin quality improvement may occur as the medication's effects lift

It is recommended to inject Wegovy, or Zepbound once weekly on the same day each week
