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I'm gonna quote Alex Telford who wrote this really amazing, long blog post explaining how the clinical trial process works, why drug development has gotten so expensive, and all that

Serena Williams is opening up about her weight loss journey with GLP-1 medication Zepbound

Pharmacologic approaches to weight management and GLP-1 receptor agonists

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Going beyond that window starts to compress or extend the gap between doses in ways that reduce the drug's effectiveness
