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Activation of GLP-1R reduced NTG-induced c-fos expression in the TNC In addition to CGRP, we also detected alterations in c-fos expression in the TNC, which is a reliable marker of neuronal activation and is considered another mediator of central sensitization

Perkovic, Vlado, et al

Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy

However comparing GLP-1s to metformin is not straightforward, as individual treatment plans may vary and the choice of medication can depend on various factors