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Renal impairment does not require dose adjustment according to the FDA label, though monitoring renal function is important, especially if severe gastrointestinal adverse effects occur, as these may lead to dehydration and acute kidney injury

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Important considerations for calculating your protein needs: Use ideal or adjusted body weight rather than current weight for calculations Distribute protein across multiple meals (0.25-0.4 g/kg per meal) Prioritize protein intake early in the day when appetite may be better If you have chronic kidney disease (CKD stage 3 or higher), follow ADA/KDIGO guidelines of approximately 0.8 g/kg/day unless otherwise directed by your nephrologist Work with a registered dietitian for personalized recommendations These targets aim to preserve lean muscle mass, support metabolic rate, and optimize body composition changes during weight loss

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