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Description
Based on the PIONEER programme, oral semaglutide has been licensed for people with T2D and the 14 mg dose, leads to HbA1c improvement up to 1.4% and WL up to 4.4 kg [20]
Among them, GLP-1 and GIP (gastric inhibitory polypeptide) are known as incretins, gut-derived hormones that enhance glucose-dependent insulin secretion, playing a pivotal role in maintaining glucose homeostasis and serve as important therapeutic targets for type 2 diabetes and obesity
105 Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial
The novel antidiabetic drugs, such as sodium glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase 4 inhibitors (DPP4i), have demonstrated beneficial effects on cardiovascular outcomes in patients with DM [11]
Sources include: Parker, C.H., Slattery, C., Brennan, D.J., & le Roux, C.W
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