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[DOI] [PubMed] 206.Salonia A., Capogrosso P., Boeri L., Cocci A., Corona G., Dinkelman-Smit M., Falcone M., Jensen C.F., Gl M., Kalkanli A., et al

In addition to providing a pharmacokinetic profile that enables once-weekly dosing, the acylation moiety of tirzepatide also contributes to the interaction with both the GIPR and GLP-1R, as well as possibly the cell membrane 50

Disrupted heart rhythm can prevent the blood from being pumped regularly

Mounjaro helped participants lose an average of 15% to 21% of their body weight over 72 weeks at the highest doses

For people with type 2 diabetes or prediabetes, both compounds improve glycemic control

27 , 29 , 40 , 43 Similarly, SURMOUNT-1, which evaluated tirzepatide, a dual GLP-1/GIP RA, reported mean reductions of 6.4 mm Hg SBP and 3.6 mm Hg DBP at the highest dose