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The gap in efficacy is large enough that it represents a genuinely different level of treatment outcome, not just a marginal improvement

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A visual analysis of funnel plots did not suggest publication bias (data not shown)

Obesity Science & Practice, 7 (6), 667-676

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avoid them if they trigger or aggravate your symptoms Alcohol can worsen nausea, impair blood glucose regulation, and interact with the metabolic effects of the drug