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As per Bradford Hills criteria 41 , the biological plausibility through GLP-1R expression in the nervous system and temporal consistency in time-to-onset analysis support potential causality, but confounding factors inherent to spontaneous reporting systems preclude definitive conclusions
SNAC protects semaglutide from being broken down by digestive enzymes in the stomach and allows it to enter the bloodstream more easily
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doi: 10.1016/S0140-6736(12)61267-7 [DOI] [PubMed] [Google Scholar] 40
