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[3] By keeping your food in your stomach longer , you feel fuller longer (in the inset graph, it's called "mechanical distention")

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Whilst these nutrients play legitimate roles in metabolic processes, supplementation beyond physiological requirements does not necessarily enhance fat burning or energy expenditure

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This would explain their nausea/emesis side effects and also support the previous experimental findings that GLP1 receptor agonists in the arcuate nucleus, rather than the area postrema, are most important for the intakesuppressive effects of these agonists (Secher et al., 2014)