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Description
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It is a structural analogue of human glucagon-like peptide 1 (GLP-1), which can mimic its effect, reduce hunger, reduce diet, and reduce calorie intake
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Additional risk factors commonly present in patients prescribed GLP-1 receptor agonists include: Reduced physical activity and prolonged immobility Hypertension and other cardiovascular comorbidities Dyslipidaemia contributing to atherosclerosis Advanced age , as thrombotic risk increases with ageing Other important VTE risk factors include: Previous VTE or family history of clotting disorders Thrombophilia (inherited or acquired clotting disorders) Active cancer or cancer treatment Oestrogen-containing medications (HRT, combined oral contraceptives) Pregnancy and postpartum period Recent surgery, trauma or hospitalisation Long-haul travel with prolonged immobility Smoking When patients taking GLP-1 receptor agonists experience thrombotic events, it is important to consider these pre-existing risk factors as they often contribute significantly to clotting risk in this population
GLP-1-induced weight loss directly translates to reduced joint stress, slowing cartilage degradation and improving mobility

Restraints High treatment costs and Limited reimbursements The escalating costs of anti-obesity medications, coupled with limited insurance reimbursements, present significant barriers to access for many patients
