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One of the concerns with GLP-1 therapy is muscle loss

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1B, the expression of TCF7L2 23 in the intima and media was clearly lower in obese subjects (lower panel) compared to non-obese subjects (upper panel)

The article also discusses the evolving evidence on GLP-1s and mental health, noting that while some studies have reported reductions in depressive symptoms, data remain limited and careful patient selection is still recommended

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron