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STEP Trials (Semaglutide Treatment Effect in People with Obesity): STEP trials evaluated semaglutide for weight management in individuals with obesity

This distinction is important: insulin is traditionally measured in international units (IU), whereas peptide-based receptor agonists like retatrutide, semaglutide, and tirzepatide are dosed by weight (milligrams)

Conversely, low-dose GLP-1 therapy is not appropriate for patients without established indications, particularly those seeking anti-inflammatory effects alone without diabetes or obesity

Should I stop my GLP-1 if I have body aches

Instead of just focusing on the scale, this approach focuses on the health of the cells that drive your metabolism

However, persistent or severe abdominal pain warrants careful evaluation to exclude more serious conditions such as pancreatitis