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By exploring human studies and mechanistic insights, this review underscores irisins potential to address global health challenges, such as obesity and type 2 diabetes, while advancing strategies for personalized exercise interventions.

Millions take GLP-1 medications, but few know their oral side effects
GLP-1 is a hormone that the gut produces after eating to regulate blood sugar, slow digestion and manage hunger
Exendin-4 allows Gila monsters to eat enormous quantities of food while maintaining a functional metabolism and stable glucose levels

Despite the hype about weight loss drugs known as GLP-1s, serious questions have remained about their efficacy when patients wean off the drugs

Fibrosis, characterised by the excessive deposition of extracellular matrix via activated fibroblasts, is a pathological feature of several chronic inflammatory disorders, which collectively contribute significantly to global morbidity and mortality