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During this time, some patients may see a slight reduction in appetite, while weight loss is often modest

In recent years, the gut-brain axis has been increasingly considered a promising topic for the study of CNS-related diseases because the gut microbiota and gut hormones have been shown to interact with other organs including the brain (Knight et al., 2017), although the mechanisms involved in gut homeostasis and brain function are as yet uncharacterized (Neufeld and Foster, 2009)
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Following 6 weeks of HFD, all mice were switched to HFD supplemented with tamoxifen to induce cell GLP-1R knockdown and were maintained on this diet throughout study, resulting in a total duration of 8 weeks of HFD feeding before intervention, which results in impaired glucose tolerance, insulin secretion, and islet function, as previously established (2628)