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Konstantinos Spaniolas, director of the Stony Brook Bariatric and Metabolic Weight Loss Center

While mild muscle discomfort during weight loss may not require immediate medical attention, certain features warrant prompt clinical evaluation to exclude serious underlying conditions

The additives commonly included in compounded formulations, such as B12 , glycine , or L-carnitine , are vitamins and amino acid derivatives that are not controlled substances and will not produce positive drug test results

Foods and Drinks to Limit To reduce the likelihood of urgent bowel movements, consider limiting the following: High-fat and fried foods: These take even longer to digest and can cause significant nausea and diarrhea when combined with a GLP-1

Microdosing is often used earlier in the weight-loss journey

On October 10, 2023 , the FDA sent letters to the National Association of Boards of Pharmacy and the Federation of State Medical Boards expressing similar concerns