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Any surgeon who tries to sell a one-size-fits-all approach to patients with GLP-1related facial change should be viewed with caution because everyones needs are unique, she said

N Engl J Med 2021;384:9891002.ArticlePubMed 18

Insurance policies keep changing

However, researchers note that consistency is a major hurdle, with more than half of users discontinuing the medication within two years, often restarting later

Additionally, treatment with GLP-1RA and exendin-4 increased the expression of the calcitonin gene in the thyroids of normal (wild-type) mice

Third, oral options like orforglipron trade some efficacy for dramatically improved convenience
