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It also increased whole-body energy expenditure in mice fed a high-fat diet and enhanced the conversion of the essential amino acid arginine into ornithine and citrulline

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Heterozygous floxed Gipr female mice with the synapsin-Cre transgene were mated to heterozygous floxed Gipr male mice without the synapsin-Cre transgene to produce homozygous floxed Gipr ( Gipr fl/fl ) mice with or without the synapsin-Cre transgene

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