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Wednesdays approval is backed by data from two Phase III studiesBE HEARD I and BE HEARD II

Nicola Magrini, Unit head for Innovation, Evidence synthesis and Clinical research, University Hospital, Bologna, Italy, Co-Chair of the Guidelines Development Group Comments: GLP-1 and inclusion in the essential medicine Mr Deus Mubangizi, Director, Medicines and Health Products Policies and Standards Department, WHO Panel discussion Ms Jeanette Hunter General Primary Health Care at the National Department of Health (NDoH) of South Africa, and Co-Chair of the Guidelines Development Group

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2016;22(7 Suppl):s176s185

This stepwise dosing approach was designed to minimize gastrointestinal symptoms (nausea, vomiting, and diarrhea) and help clinicians distinguish between the levels at which the drug remains tolerable and those that maximize therapeutic benefit