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Transition phase (discontinuationwashoutstabilization): strictly implement clearance times based on drug characteristicsdiscontinue semaglutide for 2 months, tirzepatide for at least 1 month (161), and long-acting formulations like exenatide for at least 3 months (153, 158, 159, 162)

The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke

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STAT News noted that the new deal stems from pricing negotiations rather than a full legislative overhaul

Part 2: GLP-1 Medications Beyond Weight Loss The landscape of pharmacological interventions in combating obesity has long struggled with the challenge of balancing efficacy and safety