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The most frequent side effects reported with LY3298176 were gastrointestinal (vomiting, nausea, decreased appetite, diarrhoea, and abdominal distension) in both HS and patients with T2DM

This includes premature death for the morbidly obese as well as increased risk of heart attacks, cancer risk, joint pain, immobility, infertility and depression

Around 3% of participants using the higher dose and 2% of participants using the standard dose stopped using the drug because of these gastrointestinal issues

doi: [DOI] [PubMed] [Google Scholar] 10.Plessier A, Darwish-Murad S, Hernandez-Guerra M, Consigny Y, Fabris F, Trebicka J

The presence of GLP-1R in hepatocytes, however, remains a subject of debate

The situation with an unapproved investigational compound like retatrutide is exponentially more variable