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Comparing Semaglutide, Tirzepatide, and Retatrutide Why Semaglutide Still Works for Some Patients Even though tirzepatide and retatrutide show greater average weight loss , not everyone needs (or tolerates) the most aggressive option

Key Takeaways Tirzepatide can cause nausea by slowing gastric emptying, making large or heavy meals more likely to trigger symptoms

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They give patients clear instructions for their ongoing care