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10.1016/s0140-6736(20)32205-4 [DOI] [PMC free article] [PubMed] [Google Scholar] Scherer T., Sakamoto K., Buettner C

Lowering your intake of calories may increase your chances of losing weight, maintaining your weight loss, and living a healthier lifestyle
Adipose tissue acts as an insulator , potentially impairing heat dissipation and making temperature regulation more challenging
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Gastrointestinal Symptoms Nausea, bloating, and gastrointestinal discomfort are common side effects of GLP-1 medications, particularly early in treatment or after dose increases

However, human biology differs significantly

Cost was noted to be a significant factor for patients in the USA compared to other EU countries, with 48.6% of patients reporting discontinuation due to cost in the USA vs