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The mechanisms underlying weight regain are multifactorial and include metabolic adaptation with decreased energy expenditure, hormonal changes affecting appetite regulation, anatomical alterations such as gastric pouch or stoma dilation, and psychosocial factors including maladaptive eating behaviors

If the stomach remains full for too long, it can lead to feelings of heaviness, bloating, and nausea

It works by signaling fullness to the brain and slowing how quickly food leaves the stomach

2021;29(372): n71

however, it is not yet approved for use Boehringer Ingelheim, a biopharmaceutical company headquartered in Ingelheim, Germany, has announced promising results from its Phase 3 SYNCHRONIZE-1 clinical trial testing survodutide

Highly palatable, high-calorie foods typically trigger a significant dopamine release, creating a pleasurable sensation that encourages repeat consumption