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Accessed May 6, 2023

Pharma companies like Roche, Amgen, Pfizer, and AstraZeneca are among the contenders expected to release additional obesity drugs in the next three to four years

Special considerations for different populations Not everyone responds to these medications the same way

In the isolated perfused porcine ileum, GLP-1 secretion is inhibited by electrical nerve stimulation or by administration of norepinephrine, effects that can be blocked by co-infusion of the nonselective -adrenergic receptor antagonist phentolamine [337]

Cardiac health protection Large-scale outcome trials demonstrate reductions in major cardiac events, tied to improved endothelial function, reduced inflammation, and favorable shifts in lipids and blood pressure