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Seek emergency care immediately if palpitations occur with chest pain, severe shortness of breath, dizziness, fainting, or profuse sweating

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Exendin-4 suppresses cell proliferation through the inhibition of ERK-MAPK [80]

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However, their efficacy is driven primarily by appetite suppression rather than sustained increases in energy expenditure, and adult human physiology imposes a clear ceiling on thermogenic contributions

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Even modest weight loss (510% of body weight) can lead to significant improvements in cardiovascular risk factors, glycaemic control in type 2 diabetes, sleep apnoea, joint pain, and quality of life

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(b) Mean ( s.e.m.) number of food rewards earned by mice after Ex-4 (10 g/kg) administration

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The highest dose of retatrutide had almost three times the adverse-event discontinuation rate of the highest dose of tirzepatide

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