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Due to side effects from metformin, his clinician added Ozempic, cutting his metformin dose

Looking back, that's totally wrong, of course

Most endocrinologists recommend rechecking thyroid labs 6 to 8 weeks after initiating weight loss therapy, then again every 3 to 6 months during active weight reduction

Metformin is a first-line drug for treating type 2 diabetes associated with AMPK activation

While these are averages rather than guarantees, they indicate that retatrutide is operating in a range previously seen mainly with bariatric surgery, but through a weekly injection instead of an operation
doi: 10.1159/000478872 12 SisleySGutierrez-AguilarRScottMD'AlessioDASandovalDASeeleyRJ
